XSB2833 : Insulin-like growth factor-binding protein 4
[ CaMP Format ]
This entry is computationally expanded from SB0070
* Basic Information
| Organism | Ovis aries (sheep) |
| Protein Names | IGF-binding protein 4; IGFBP-4; IBP-4 |
| Gene Names | IGFBP4 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| Q28893 | N/A | N/A | IBP4_SHEEP | N/A | N/A | N/A | N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 237 aa
Average Mass: 25.869 kDa
Monoisotopic Mass: 25.852 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| IGFBP 1. | 6 | 64 | 96.5 | 9e-26 |
| --- cleavage 122 --- | ||||
| --- cleavage 138 --- | ||||
| --- cleavage 86 --- | ||||
| Thyroglobulin_1 1. | 153 | 228 | 144.0 | 4.7e-40 |
3. Sequence Information
Fasta Sequence: XSB2833.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
3 [sites]
Cleavage sites (±10aa)
[Site 1] HDRKCLQKHL122-AKIRDRSTSG
Leu122 
Ala
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| His113 | Asp114 | Arg115 | Lys116 | Cys117 | Leu118 | Gln119 | Lys120 | His121 | Leu122 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala123 | Lys124 | Ile125 | Arg126 | Asp127 | Arg128 | Ser129 | Thr130 | Ser131 | Gly132 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| QPSDKDEGDHPNNSFSPCSAHDRKCLQKHLAKIRDRSTSGGKMKVIGAPREEVRPVPQGS |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Ovis aries | 129.00 | 1 | IBP4_SHEEP Insulin-like growth factor-binding prot |
| 2 | Bos taurus | 128.00 | 2 | insulin-like growth factor binding protein 4 |
| 3 | Canis familiaris | 124.00 | 1 | PREDICTED: similar to Insulin-like growth factor b |
| 4 | Equus caballus | 123.00 | 1 | insulin-like growth factor binding protein-4 |
| 5 | Sus scrofa | 122.00 | 1 | IBP4 |
| 6 | Homo sapiens | 121.00 | 2 | insulin-like growth factor binding protein 4 precu |
| 7 | N/A | 121.00 | 2 | - |
| 8 | synthetic construct | 121.00 | 2 | insulin-like growth factor binding protein 4 |
| 9 | Pan troglodytes | 121.00 | 1 | PREDICTED: similar to Insulin-like growth factor-b |
| 10 | Mus musculus | 99.40 | 3 | insulin-like growth factor binding protein 4 |
| 11 | Rattus norvegicus | 99.40 | 2 | insulin-like growth factor binding protein 4 |
| 12 | Monodelphis domestica | 85.10 | 1 | PREDICTED: similar to SWI/SNF-related matrix-assoc |
| 13 | Gallus gallus | 75.50 | 1 | insulin-like growth factor binding protein 4 |
| 14 | Bubalus bubalis | 74.70 | 1 | insulin-like growth factor binding protein-4 |
| 15 | Tetraodon nigroviridis | 37.00 | 1 | unnamed protein product |
| 16 | Oncorhynchus mykiss | 37.00 | 1 | insulin-like growth factor binding protein 4 |
Top-ranked sequences
| organism | matching |
|---|---|
| Ovis aries | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 |
| Bos taurus | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 ||||||||||||||||||||||||||||||#|||||||||||||||||||||| ||||||| Sbjct 114 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 173 |
| Canis familiaris | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 |||||||||||||||||||||||+||||| #||||||||||||||||| |||| ||||||| Sbjct 307 QPSDKDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVIGVPREEARPVPQGS 366 |
| Equus caballus | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 |||||||||||||||||||||||+||||| #|||||||||||||||+| |||| ||||||| Sbjct 93 QPSDKDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVVGVPREEARPVPQGS 152 |
| Sus scrofa | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 ||||||||||||||||||| ||+||||||#|||||||||||||||||||||| ||||||| Sbjct 115 QPSDKDEGDHPNNSFSPCSPQDRRCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 174 |
| Homo sapiens | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 |||||||||||||||||||||||+||||| #||||||||||||||| |||||+ ||||||| Sbjct 114 QPSDKDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVNGAPREDARPVPQGS 173 |
| N/A | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 |||||||||||||||||||||||+||||| #||||||||||||||| |||||+ ||||||| Sbjct 114 QPSDKDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVNGAPREDARPVPQGS 173 |
| synthetic construct | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 |||||||||||||||||||||||+||||| #||||||||||||||| |||||+ ||||||| Sbjct 114 QPSDKDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVNGAPREDARPVPQGS 173 |
| Pan troglodytes | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 |||||||||||||||||||||||+||||| #||||||||||||||| |||||+ ||||||| Sbjct 114 QPSDKDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVNGAPREDARPVPQGS 173 |
| Mus musculus | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 | ||||| +||||||+|||||| +|||||+#||||||| |||++| |||| ||||||| Sbjct 114 QTSDKDESEHPNNSFNPCSAHDHRCLQKHM#AKIRDRS----KMKIVGTPREEPRPVPQGS 169 |
| Rattus norvegicus | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 | ||||| +||||||+|||||| +|||||+#||+|||| ||||+| |||| ||||||| Sbjct 114 QTSDKDESEHPNNSFNPCSAHDHRCLQKHM#AKVRDRS----KMKVVGTPREEPRPVPQGS 169 |
| Monodelphis domestica | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIG--APREEVRPVPQ 150 | ++|+| +||||||||||+|||||+||| #|||| |++ |||| || | ||+ ||+ | Sbjct 114 QTTEKEESEHPNNSFSPCSSHDRKCMQKHS#AKIRVVSSNSGKMKSIGSSAHREDTRPMAQ 173 Query 151 GS 152 || Query 151 GS 152 |
| Gallus gallus | Query 93 QPSDKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAP--REEVRPVPQ 150 || +|+| +|||||||||| |||||||| #|| | +| ||+ |+| ||| ||+ | Sbjct 119 QPPEKEEIEHPNNSFSPCSIHDRKCLQKQQ#AK---RINNGNKMRSSGSPHHREESRPIAQ 175 Query 151 GS 152 || Query 151 GS 152 |
| Bubalus bubalis | Query 117 CLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 ||||||#|||||||||||||||||||||| ||||||| Sbjct 1 CLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 36 |
| Tetraodon nigroviridis | Query 101 DHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTS 131 +||||| || |++|+|| |#|+ +||+ Sbjct 130 EHPNNSNIRCSQQDKRCIQKTL#ARHLSKSTN 160 |
| Oncorhynchus mykiss | Query 96 DKDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRP 147 |+ +||||| || |++|+|| |#|+ +||+ |+ + | Sbjct 5 DETIPEHPNNSNIRCSPQDKRCIQKTL#ARHPAKSTNQRSNNAREDPKAALAP 56 |
[Site 2] STSGGKMKVI138-GAPREEVRPV
Ile138 Gly
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser129 | Thr130 | Ser131 | Gly132 | Gly133 | Lys134 | Met135 | Lys136 | Val137 | Ile138 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly139 | Ala140 | Pro141 | Arg142 | Glu143 | Glu144 | Val145 | Arg146 | Pro147 | Val148 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PCSAHDRKCLQKHLAKIRDRSTSGGKMKVIGAPREEVRPVPQGSCQSELHRALERLAASQ |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Ovis aries | 125.00 | 1 | IBP4_SHEEP Insulin-like growth factor-binding prot |
| 2 | Bos taurus | 123.00 | 2 | insulin-like growth factor binding protein 4 |
| 3 | Canis familiaris | 119.00 | 1 | PREDICTED: similar to Insulin-like growth factor b |
| 4 | Equus caballus | 119.00 | 1 | insulin-like growth factor binding protein-4 |
| 5 | N/A | 117.00 | 3 | - |
| 6 | Homo sapiens | 117.00 | 2 | insulin-like growth factor binding protein 4 precu |
| 7 | synthetic construct | 117.00 | 2 | insulin-like growth factor binding protein 4 |
| 8 | Pan troglodytes | 117.00 | 1 | PREDICTED: similar to Insulin-like growth factor-b |
| 9 | Sus scrofa | 117.00 | 1 | IBP4 |
| 10 | Bubalus bubalis | 105.00 | 1 | insulin-like growth factor binding protein-4 |
| 11 | Mus musculus | 102.00 | 3 | insulin-like growth factor binding protein-4 |
| 12 | Rattus norvegicus | 102.00 | 1 | insulin-like growth factor binding protein 4 |
| 13 | Monodelphis domestica | 90.10 | 1 | PREDICTED: similar to SWI/SNF-related matrix-assoc |
| 14 | Gallus gallus | 81.30 | 1 | insulin-like growth factor binding protein 4 |
| 15 | Tetraodon nigroviridis | 40.40 | 1 | unnamed protein product |
| 16 | Oncorhynchus mykiss | 38.10 | 1 | insulin-like growth factor binding protein 4 |
Top-ranked sequences
| organism | matching |
|---|---|
| Ovis aries | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |
| Bos taurus | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 ||||||||||||||||||||||||||||||#|||||| ||||||||||||||||||||||| Sbjct 130 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 189 |
| Canis familiaris | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |||||||+||||| ||||||||||||||||#| |||| ||||||||||||||||||||||| Sbjct 323 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVI#GVPREEARPVPQGSCQSELHRALERLAASQ 382 |
| Equus caballus | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |||||||+||||| |||||||||||||||+#| |||| ||||||||||||||||||||||| Sbjct 109 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVV#GVPREEARPVPQGSCQSELHRALERLAASQ 168 |
| N/A | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |||||||+||||| ||||||||||||||| #|||||+ ||||||||||||||||||||||| Sbjct 130 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVN#GAPREDARPVPQGSCQSELHRALERLAASQ 189 |
| Homo sapiens | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |||||||+||||| ||||||||||||||| #|||||+ ||||||||||||||||||||||| Sbjct 130 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVN#GAPREDARPVPQGSCQSELHRALERLAASQ 189 |
| synthetic construct | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |||||||+||||| ||||||||||||||| #|||||+ ||||||||||||||||||||||| Sbjct 130 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVN#GAPREDARPVPQGSCQSELHRALERLAASQ 189 |
| Pan troglodytes | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |||||||+||||| ||||||||||||||| #|||||+ ||||||||||||||||||||||| Sbjct 130 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVN#GAPREDARPVPQGSCQSELHRALERLAASQ 189 |
| Sus scrofa | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 ||| ||+||||||||||||||||||||||#|||||| ||||||||||||||||||||||| Sbjct 131 PCSPQDRRCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 190 |
| Bubalus bubalis | Query 117 CLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 ||||||||||||||||||||||#|||||| ||||||||||||||||||||||| Sbjct 1 CLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 52 |
| Mus musculus | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |||||| +|||||+||||||| |||++#| |||| ||||||||||||||||||||||| Sbjct 130 PCSAHDHRCLQKHMAKIRDRS----KMKIV#GTPREEPRPVPQGSCQSELHRALERLAASQ 185 |
| Rattus norvegicus | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |||||| +|||||+||+|||| ||||+#| |||| ||||||||||||||||||||||| Sbjct 130 PCSAHDHRCLQKHMAKVRDRS----KMKVV#GTPREEPRPVPQGSCQSELHRALERLAASQ 185 |
| Monodelphis domestica | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#G--APREEVRPVPQGSCQSELHRALERLAA 166 |||+|||||+||| |||| |++ |||| |#| | ||+ ||+ ||||||||||||||| | Sbjct 130 PCSSHDRKCMQKHSAKIRVVSSNSGKMKSI#GSSAHREDTRPMAQGSCQSELHRALERLGA 189 Query 167 SQ 168 || Query 167 SQ 168 |
| Gallus gallus | Query 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAP--REEVRPVPQGSCQSELHRALERLAA 166 ||| |||||||| || | +| ||+ #|+| ||| ||+ ||||||||||||||||| Sbjct 135 PCSIHDRKCLQKQQAK---RINNGNKMRSS#GSPHHREESRPIAQGSCQSELHRALERLAA 191 Query 167 SQ 168 || Query 167 SQ 168 |
| Tetraodon nigroviridis | Query 110 CSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAAS 167 || |++|+|| ||+ +||+ + # + ||| + | |++|| |||+|||++ Sbjct 139 CSQQDKRCIQKTLARHLSKSTN----QRS#NSGREETKAV-LAPCRAELQRALDRLASN 191 |
| Oncorhynchus mykiss | Query 110 CSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAAS 167 || |++|+|| ||+ +||+ # |+ + | |++|| |||+|| ++ Sbjct 19 CSPQDKRCIQKTLARHPAKSTNQRSNNAR#EDPKAALAP-----CRAELQRALDRLVSN 71 |
[Site 3] GVCMELAEIE86-AIQESLQPSD
Glu86 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly77 | Val78 | Cys79 | Met80 | Glu81 | Leu82 | Ala83 | Glu84 | Ile85 | Glu86 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala87 | Ile88 | Gln89 | Glu90 | Ser91 | Leu92 | Gln93 | Pro94 | Ser95 | Asp96 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LRCHPPRGVEKPLHTLVHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRK |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Ovis aries | 132.00 | 3 | IBP4_SHEEP Insulin-like growth factor-binding prot |
| 2 | Bos taurus | 130.00 | 5 | insulin-like growth factor binding protein 4 |
| 3 | Homo sapiens | 127.00 | 15 | insulin-like growth factor binding protein 4 |
| 4 | N/A | 127.00 | 11 | - |
| 5 | synthetic construct | 127.00 | 10 | insulin-like growth factor binding protein 4 |
| 6 | Canis familiaris | 126.00 | 4 | PREDICTED: similar to Insulin-like growth factor b |
| 7 | Pan troglodytes | 126.00 | 3 | PREDICTED: similar to Insulin-like growth factor-b |
| 8 | Equus caballus | 126.00 | 2 | insulin-like growth factor binding protein-4 |
| 9 | Sus scrofa | 121.00 | 5 | IBP4 |
| 10 | Monodelphis domestica | 113.00 | 4 | PREDICTED: similar to SWI/SNF-related matrix-assoc |
| 11 | Mus musculus | 110.00 | 9 | unnamed protein product |
| 12 | Rattus norvegicus | 110.00 | 5 | insulin-like growth factor binding protein 4 |
| 13 | Gallus gallus | 108.00 | 3 | insulin-like growth factor binding protein 4 |
| 14 | Tetraodon nigroviridis | 66.60 | 5 | unnamed protein product |
| 15 | Xenopus laevis | 46.20 | 3 | insulin-like growth factor binding protein 1 |
| 16 | Xenopus tropicalis | 45.80 | 3 | insulin-like growth factor binding protein 1 |
| 17 | Danio rerio | 40.40 | 9 | PREDICTED: similar to Igfbp5 protein |
| 18 | Salmo salar | 40.00 | 3 | IGF binding protein 5 |
| 19 | Oncorhynchus mykiss | 40.00 | 2 | insulin-like growth factor binding protein 5 |
| 20 | Macaca mulatta | 39.30 | 5 | PREDICTED: similar to insulin-like growth factor b |
| 21 | Bubalus bubalis | 38.50 | 1 | insulin-like growth factor binding protein-5 |
| 22 | Coturnix japonica | 38.10 | 1 | AF293839_1 insulin-like growth factor binding prot |
| 23 | Oncorhynchus tshawytscha | 32.70 | 1 | insulin-like growth factor binding protein-1 |
Top-ranked sequences
| organism | matching |
|---|---|
| Ovis aries | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |
| Bos taurus | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 78 LRCYPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 137 |
| Homo sapiens | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||||||||+|||||||||||||#|||||||||||||||||||||||||||||+ Sbjct 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |
| N/A | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||||||||+|||||||||||||#|||||||||||||||||||||||||||||+ Sbjct 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |
| synthetic construct | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||||||||+|||||||||||||#|||||||||||||||||||||||||||||+ Sbjct 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |
| Canis familiaris | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||||||||+|||||||||+|||#|||||||||||||||||||||||||||||+ Sbjct 271 LRCYPPRGVEKPLHTLMHGQGVCMELSEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 330 |
| Pan troglodytes | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||||||||+||||+||||||||#|||||||||||||||||||||||||||||+ Sbjct 78 LRCYPPRGVEKPLHTLMHGQGLCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |
| Equus caballus | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||||||||+|||||||||||||#||||+||||||||||||||||||||||||+ Sbjct 57 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQENLQPSDKDEGDHPNNSFSPCSAHDRR 116 |
| Sus scrofa | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||||||||+||||+||||||||#||||||||||||||||||||||||| ||+ Sbjct 79 LRCYPPRGVEKPLHTLMHGQGLCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSPQDRR 138 |
| Monodelphis domestica | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||||||||+|||| |||||+||#||||||| ++|+| +||||||||||+|||| Sbjct 78 LRCYPPRGVEKPLHTLMHGQGECMELADIE#AIQESLQTTEKEESEHPNNSFSPCSSHDRK 137 |
| Mus musculus | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 +||+||||||||| ||+|||||| ||+|||#||||||| ||||| +||||||+|||||| + Sbjct 78 MRCYPPRGVEKPLRTLMHGQGVCTELSEIE#AIQESLQTSDKDESEHPNNSFNPCSAHDHR 137 |
| Rattus norvegicus | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 +||+||||||||| ||+|||||| ||+|||#||||||| ||||| +||||||+|||||| + Sbjct 78 MRCYPPRGVEKPLRTLMHGQGVCTELSEIE#AIQESLQTSDKDESEHPNNSFNPCSAHDHR 137 |
| Gallus gallus | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||| +|||||+|||||| +||++|#|||||||| +|+| +|||||||||| |||| Sbjct 83 LRCYPPRGVPRPLHTLMHGQGVCTDLADVE#AIQESLQPPEKEEIEHPNNSFSPCSIHDRK 142 |
| Tetraodon nigroviridis | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |||+||||||+|||+|+|||||| + |+|# + |+ +||||| || |++ Sbjct 87 LRCYPPRGVERPLHSLMHGQGVCTDEREVE#E-NSATDRQDEIIPEHPNNSNIRCSQQDKR 145 |
| Xenopus laevis | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPN 104 | ||| | +||+ | |||+||+ +++# ++ | || +| | Sbjct 82 LSCHPKAGETRPLYALTRGQGICMDADDLK#RLRPSEAADGKDYAEHEN 129 |
| Xenopus tropicalis | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPN 104 | ||| | +||+ | |||+||+ +++# ++ | || +| | Sbjct 82 LSCHPKAGESRPLYALTRGQGICMDAEDLK#KLRASDAADGKDYTEHEN 129 |
| Danio rerio | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDR 115 ||| | | ||||| |+||+||| +# + | |++ +| +++ | + |+ Sbjct 74 LRCLPRNGEEKPLHALLHGRGVC---TNEK#GYKPPHPPIDRESIEH-DDTVKPDTTEDQ 128 |
| Salmo salar | Query 57 LRCHPPRGVEKPLHTLVHGQGVC 79 ||| | | ||||| |+||+||| Sbjct 76 LRCLPRNGEEKPLHALLHGRGVC 98 |
| Oncorhynchus mykiss | Query 57 LRCHPPRGVEKPLHTLVHGQGVC 79 ||| | | ||||| |+||+||| Sbjct 76 LRCLPRNGEEKPLHALLHGRGVC 98 |
| Macaca mulatta | Query 57 LRCHPPRGVEKPLHTLVHGQGVCME----LAEIE#AIQESLQPSDKDEGDHPNNSFSP 109 ||| | + ||||| |+||+|||+ +++# ++| + + + ++|| Sbjct 78 LRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVK#IERDSREHEEPTTSEMAEETYSP 134 |
| Bubalus bubalis | Query 57 LRCHPPRGVEKPLHTLVHGQGVCM 80 ||| | + ||||| |+||+|||+ Sbjct 34 LRCLPRQDEEKPLHALLHGRGVCL 57 |
| Coturnix japonica | Query 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNS 106 +|| | +| ||||| |+|| || |+| # +++ + | + | | Sbjct 34 VRCLPRQGEEKPLHALLHGTAVC--LSEKS#YREQAKAERESREHEEPTTS 81 |
| Oncorhynchus tshawytscha | Query 57 LRCHPPRGVEKPLHTLVHGQGVCME 81 |+| | | +|||+| || +| | Sbjct 88 LKCSPRAGDPRPLHSLTRGQAICTE 112 |
* References
[PubMed ID: 7531449] Carr JM, Grant PA, Francis GL, Owens JA, Wallace JC, Walton PE, Isolation and characterization of ovine IGFBP-4: protein purification and cDNA sequence. J Mol Endocrinol. 1994 Oct;13(2):219-36.