logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2837 : Chain A, Thioredoxin Peroxidase B From Red Blood Cells

[ CaMP Format ]

This entry is computationally expanded from SB0091

* Basic Information

OrganismHomo sapiens (human)
Protein NamesPeroxiredoxin-2; 1.11.1.15; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thiol-specific antioxidant protein; TSA; PRP; Natural killer cell-enhancing factor B; NKEF-B
Gene NamesNKEFB, TDPX1; NKEFB; TDPX1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1QMV_A N/A N/A PRDX2_HUMAN N/A N/A N/A hsa:7001

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 197 aa

Average Mass: 0.000 kDa

Monoisotopic Mass: 0.000 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
AhpC-TSA 1. 7140208.22.2e-59
1-cysPrx_C 1. 15019387.64.5e-23
--- cleavage 180 (inside 1-cysPrx_C 150..193) ---
--- cleavage 193 (inside 1-cysPrx_C 150..193) ---
--- cleavage 181 (inside 1-cysPrx_C 150..193) ---
--- cleavage 192 (inside 1-cysPrx_C 150..193) ---
--- cleavage 182 (inside 1-cysPrx_C 150..193) ---

3. Sequence Information

Fasta Sequence: XSB2837.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1QMV (X-ray; 170 A; A/B/C/D/E/F/G/H/I/J=2-198)

* Cleavage Information

5 [sites]

Cleavage sites (±10aa)

[Site 1] CPAGWKPGSD180-TIKPNVDDSK

Asp180 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Cys171Pro172Ala173Gly174Trp175Lys176Pro177Gly178Ser179Asp180
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr181Ile182Lys183Pro184Asn185Val186Asp187Asp188Ser189Lys190

Sequence conservation (by blast)

[Site 2] PNVDDSKEYF193-SKHN

Phe193 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro184Asn185Val186Asp187Asp188Ser189Lys190Glu191Tyr192Phe193
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser194Lys195His196Asn197------

Sequence conservation (by blast)

[Site 3] PAGWKPGSDT181-IKPNVDDSKE

Thr181 Ile

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro172Ala173Gly174Trp175Lys176Pro177Gly178Ser179Asp180Thr181
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ile182Lys183Pro184Asn185Val186Asp187Asp188Ser189Lys190Glu191

Sequence conservation (by blast)

[Site 4] KPNVDDSKEY192-FSKHN

Tyr192 Phe

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys183Pro184Asn185Val186Asp187Asp188Ser189Lys190Glu191Tyr192
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Phe193Ser194Lys195His196Asn197-----

Sequence conservation (by blast)

[Site 5] AGWKPGSDTI182-KPNVDDSKEY

Ile182 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala173Gly174Trp175Lys176Pro177Gly178Ser179Asp180Thr181Ile182
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys183Pro184Asn185Val186Asp187Asp188Ser189Lys190Glu191Tyr192

Sequence conservation (by blast)

* References

[PubMed ID: 9602152] Schroder E, Willis AC, Ponting CP, Porcine natural-killer-enhancing factor-B: oligomerisation and identification as a calpain substrate in vitro. Biochim Biophys Acta. 1998 Apr 2;1383(2):279-91.

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