XSB2857 : preproneurotensin/neuromedin N
[ CaMP Format ]
This entry is computationally expanded from SB0034
* Basic Information
| Organism | Bos taurus (cattle) |
| Protein Names | Neurotensin/neuromedin N; Large neuromedin N; NmN-125; Neuromedin N; NmN; NN; Neurotensin; NT; Tail peptide |
| Gene Names | NTS |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 169 aa
Average Mass: 19.712 kDa
Monoisotopic Mass: 19.699 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| Pro-NT_NN 1. | 1 | 169 | 491.9 | 8.6e-145 |
| --- cleavage 152 (inside Pro-NT_NN 1..169) --- |
| --- cleavage 157 (inside Pro-NT_NN 1..169) --- |
3. Sequence Information
Fasta Sequence: XSB2857.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] IPYILKRQLY152-ENKPRRPYIL
Tyr152 
Glu
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Ile143 | Pro144 | Tyr145 | Ile146 | Leu147 | Lys148 | Arg149 | Gln150 | Leu151 | Tyr152 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Glu153 | Asn154 | Lys155 | Pro156 | Arg157 | Arg158 | Pro159 | Tyr160 | Ile161 | Leu162 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
EDILDAGNDKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRGSYYY
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Contains: Large neuromedin N (NmN-125); Neuromedin N (NmN) (NN); Neurotensin (NT); Tail peptide |
100.00 |
2 |
NEUT_BOVIN Neurotensin/neuromedin N precursor |
| 2 |
Bos taurus |
100.00 |
1 |
neurotensin |
| 3 |
Canis familiaris |
100.00 |
1 |
PREDICTED: similar to Neurotensin/neuromedin N pre |
| 4 |
Pan troglodytes |
96.30 |
3 |
PREDICTED: neurotensin/neuromedin N isoform 3 |
| 5 |
Macaca mulatta |
96.30 |
1 |
PREDICTED: neurotensin |
| 6 |
Macaca fascicularis |
96.30 |
1 |
hypothetical protein |
| 7 |
Mus musculus |
94.70 |
1 |
neurotensin |
| 8 |
Homo sapiens |
93.60 |
3 |
neurotensin/neuromedin N preproprotein |
| 9 |
N/A |
92.00 |
1 |
- |
| 10 |
Rattus norvegicus |
92.00 |
1 |
PREDICTED: similar to Neurotensin/neuromedin N pre |
| 11 |
Monodelphis domestica |
70.90 |
1 |
PREDICTED: similar to Neurotensin/neuromedin N pre |
| 12 |
Xenopus laevis |
64.70 |
1 |
MGC84018 protein |
| 13 |
Gallus gallus |
60.80 |
1 |
PREDICTED: similar to Neurotensin/neuromedin N pre |
Top-ranked sequences
| organism | matching |
|---|
| Contains: Large neuromedin N (NmN-125); Neuromedin N (NmN) (NN); Neurotensin (NT); Tail peptide |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||||||||||||||||||||||||||||||#|||||||||||||||||
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
|
| Bos taurus |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||||||||||||||||||||||||||||||#|||||||||||||||||
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
|
| Canis familiaris |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||+|||||||||||||||||||||||||||#|||||||||||||||||
Sbjct 124 EDVLDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 170
|
| Pan troglodytes |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||||| ||||||||||||||||||||||||#|||||||||||| ||||
Sbjct 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170
|
| Macaca mulatta |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||||| ||||||||||||||||||||||||#|||||||||||| ||||
Sbjct 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170
|
| Macaca fascicularis |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||||| ||||||||||||||||||||||||#|||||||||||| ||||
Sbjct 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170
|
| Mus musculus |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||||| |||||||||||||||||||||||#|||||||||||||||||
Sbjct 123 EDILDNVNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
|
| Homo sapiens |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||||| ||||| ||||||||||||||||||#|||||||||||| ||||
Sbjct 124 EDILDTGNDKNGKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170
|
| N/A |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||||| ||+| |||||||||||||||||||#|||||||||||| ||||
Sbjct 79 EDILDHGNEKTEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRASYYY 125
|
| Rattus norvegicus |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
||||| ||+| |||||||||||||||||||#|||||||||||| ||||
Sbjct 123 EDILDHGNEKTEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRASYYY 169
|
| Monodelphis domestica |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
+|||+ || |||||+||| |||||||++# || |||||||| | ||
Sbjct 119 DDILETGNLNREKEEVMKRKTPYILKRQIH#VNKARRPYILKRSSSYY 165
|
| Xenopus laevis |
Query 124 DILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYY 168
| |+ + +||+| |||| ||||||| |# +| ||||||||||||
Sbjct 122 DYLEPNSPNSEKDEPIKRKTPYILKRQTY#VSKARRPYILKRGSYY 166
|
| Gallus gallus |
Query 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYY 168
+| | | ||| ++||| ||||||||+# || |||||||| |||
Sbjct 120 QDAFDLENSSQEKE-IMKRKNPYILKRQLH#VNKARRPYILKRSSYY 164
|
[Site 2] KRQLYENKPR157-RPYILKRGSY
Arg157 Arg
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Lys148 | Arg149 | Gln150 | Leu151 | Tyr152 | Glu153 | Asn154 | Lys155 | Pro156 | Arg157 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Arg158 | Pro159 | Tyr160 | Ile161 | Leu162 | Lys163 | Arg164 | Gly165 | Ser166 | Tyr167 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
AGNDKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRGSYYY
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Contains: Large neuromedin N (NmN-125); Neuromedin N (NmN) (NN); Neurotensin (NT); Tail peptide |
90.90 |
2 |
NEUT_BOVIN Neurotensin/neuromedin N precursor |
| 2 |
Bos taurus |
90.90 |
1 |
neurotensin |
| 3 |
Canis familiaris |
90.90 |
1 |
PREDICTED: similar to Neurotensin/neuromedin N pre |
| 4 |
Mus musculus |
87.00 |
1 |
neurotensin |
| 5 |
Pan troglodytes |
86.70 |
3 |
PREDICTED: similar to proneurotensin/proneuromedin |
| 6 |
Macaca mulatta |
86.70 |
1 |
PREDICTED: neurotensin |
| 7 |
Macaca fascicularis |
86.70 |
1 |
hypothetical protein |
| 8 |
Homo sapiens |
84.00 |
3 |
neurotensin/neuromedin N preproprotein |
| 9 |
N/A |
83.20 |
1 |
- |
| 10 |
Rattus norvegicus |
83.20 |
1 |
PREDICTED: similar to Neurotensin/neuromedin N pre |
| 11 |
Monodelphis domestica |
63.90 |
1 |
PREDICTED: similar to Neurotensin/neuromedin N pre |
| 12 |
Xenopus laevis |
60.80 |
1 |
MGC84018 protein |
| 13 |
Gallus gallus |
57.80 |
1 |
PREDICTED: similar to Neurotensin/neuromedin N pre |
Top-ranked sequences
| organism | matching |
|---|
| Contains: Large neuromedin N (NmN-125); Neuromedin N (NmN) (NN); Neurotensin (NT); Tail peptide |
Query 128 AGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
||||||||||||||||||||||||||||||#||||||||||||
Query 128 AGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
|
| Bos taurus |
Query 128 AGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
||||||||||||||||||||||||||||||#||||||||||||
Query 128 AGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
|
| Canis familiaris |
Query 128 AGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
||||||||||||||||||||||||||||||#||||||||||||
Query 128 AGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
|
| Mus musculus |
Query 130 NDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
||||||||||||||||||||||||||||#||||||||||||
Query 130 NDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
|
| Pan troglodytes |
Query 129 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
|||||||||||||||||||||||||||||#||||||| ||||
Sbjct 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170
|
| Macaca mulatta |
Query 129 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
|||||||||||||||||||||||||||||#||||||| ||||
Sbjct 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170
|
| Macaca fascicularis |
Query 129 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
|||||||||||||||||||||||||||||#||||||| ||||
Sbjct 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170
|
| Homo sapiens |
Query 129 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
||||| |||||||||||||||||||||||#||||||| ||||
Sbjct 130 GNDKNGKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170
|
| N/A |
Query 129 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
||+| ||||||||||||||||||||||||#||||||| ||||
Sbjct 85 GNEKTEKEEVIKRKIPYILKRQLYENKPR#RPYILKRASYYY 125
|
| Rattus norvegicus |
Query 129 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
||+| ||||||||||||||||||||||||#||||||| ||||
Sbjct 129 GNEKTEKEEVIKRKIPYILKRQLYENKPR#RPYILKRASYYY 169
|
| Monodelphis domestica |
Query 129 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
|| |||||+||| |||||||++ || |#||||||| | ||
Sbjct 125 GNLNREKEEVMKRKTPYILKRQIHVNKAR#RPYILKRSSSYY 165
|
| Xenopus laevis |
Query 133 NEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYY 168
+||+| |||| ||||||| | +| |#|||||||||||
Sbjct 131 SEKDEPIKRKTPYILKRQTYVSKAR#RPYILKRGSYY 166
|
| Gallus gallus |
Query 131 DKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYY 168
+ ++++|++||| ||||||||+ || |#||||||| |||
Sbjct 127 NSSQEKEIMKRKNPYILKRQLHVNKAR#RPYILKRSSYY 164
|
* References
[PubMed ID: 2832414] Kislauskis E, Bullock B, McNeil S, Dobner PR, The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences. J Biol Chem. 1988 Apr 5;263(10):4963-8.
