CaMPDB :: Substrate

XSB2876 : Spectrin beta chain, erythrocyte

This entry is computationally expanded from SB0052

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	Beta-I spectrin
Gene Names	Spnb-1, Spnb1, Sptb1; Spnb-1; Spnb1; Sptb1
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
P15508	N/A	N/A	SPTB1_MOUSE	N/A	N/A	N/A	mmu:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2128 aa

Average Mass: 245.250 kDa

Monoisotopic Mass: 245.098 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
CH 1.	55	158	118.2	2.7e-32
CH 2.	174	278	148.9	1.5e-41
Spectrin 1.	302	412	69.4	1.3e-17
Spectrin 2.	414	518	105.3	2.1e-28
Spectrin 3.	520	627	91.9	2.2e-24
Spectrin 4.	629	733	126.6	8.1e-35
Spectrin 5.	735	838	101.2	3.4e-27
Spectrin 6.	840	944	58.7	2.1e-14
Spectrin 7.	946	1051	74.6	3.7e-19
Spectrin 8.	1053	1158	94.8	2.9e-25
Spectrin 9.	1160	1264	17.1	0.0012
Spectrin 10.	1266	1369	108.7	1.9e-29
Spectrin 11.	1373	1468	25.3	0.00024
Spectrin 12.	1470	1574	75.8	1.6e-19
Spectrin 13.	1576	1680	89.8	9.4e-24
Spectrin 14.	1682	1786	107.1	6.1e-29
Spectrin 15.	1788	1892	85.3	2.2e-22
Spectrin 16.	1894	1998	100.5	5.8e-27
Spectrin 17.	2000	2108	26.4	0.00012
--- cleavage 2052 (inside Spectrin 2000..2108) ---

3. Sequence Information

Fasta Sequence: XSB2876.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] EAFEKSTASW²⁰⁵²-AERFAALEKP

Trp²⁰⁵² Ala

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Glu²⁰⁴³	Ala²⁰⁴⁴	Phe²⁰⁴⁵	Glu²⁰⁴⁶	Lys²⁰⁴⁷	Ser²⁰⁴⁸	Thr²⁰⁴⁹	Ala²⁰⁵⁰	Ser²⁰⁵¹	Trp²⁰⁵²

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ala²⁰⁵³	Glu²⁰⁵⁴	Arg²⁰⁵⁵	Phe²⁰⁵⁶	Ala²⁰⁵⁷	Ala²⁰⁵⁸	Leu²⁰⁵⁹	Glu²⁰⁶⁰	Lys²⁰⁶¹	Pro²⁰⁶²

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
LASRDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQTPERPTEEPGP

Summary

#	organism	max score	hits	top seq
1	Mus musculus	94.00	47	mKIAA4219 protein
2	Homo sapiens	91.30	61	spectrin, beta, erythrocytic (includes spherocytos
3	N/A	91.30	15	-
4	Danio rerio	72.40	9	spectrin, beta, erythrocytic
5	Gallus gallus	70.50	6	PREDICTED: similar to spectrin, beta, non-erythroc
6	Canis familiaris	69.30	19	PREDICTED: similar to spectrin, beta, non-erythroc
7	Pan troglodytes	69.30	14	PREDICTED: spectrin, beta, non-erythrocytic 1 isof
8	Rattus norvegicus	69.30	13	spectrin beta 2
9	Macaca mulatta	69.30	5	PREDICTED: spectrin, beta, non-erythrocytic 1 isof
10	Bos taurus	69.30	5	PREDICTED: similar to spectrin, beta, non-erythroc
11	Macaca fascicularis	69.30	2	unnamed protein product
12	mice, brain, Peptide Partial, 332 aa	69.30	1	beta-spectrin subunit
13	Tetraodon nigroviridis	63.90	8	unnamed protein product
14	Drosophila melanogaster	63.20	8	beta Spectrin CG5870-PA
15	Aedes aegypti	63.20	3	beta chain spectrin
16	Drosophila pseudoobscura	63.20	3	GA19192-PA
17	Anopheles gambiae str. PEST	63.20	3	ENSANGP00000012507
18	Tribolium castaneum	62.00	4	PREDICTED: similar to Spectrin beta chain isoform
19	Apis mellifera	62.00	3	PREDICTED: similar to Spectrin beta chain
20	Strongylocentrotus purpuratus	57.80	5	PREDICTED: similar to spectrin beta 2
21	Caenorhabditis briggsae	55.10	2	Hypothetical protein CBG19038
22	Brugia malayi	53.90	1	beta-G spectrin
23	Caenorhabditis elegans	53.50	5	UNCoordinated family member (unc-70)
24	Sus scrofa	41.60	1	spectrin alpha non-erythrocytic 1
25	Monodelphis domestica	35.80	4	PREDICTED: similar to spectrin, beta, erythrocytic
26	Mus sp.	34.70	1	SPTB1_MOUSE Spectrin beta chain, erythrocyte (Beta
27	Xenopus tropicalis	32.30	1	hypothetical protein LOC100036647

Top-ranked sequences

organism	matching
Mus musculus	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068
Homo sapiens	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1404 LASGDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 1449
N/A	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 978 LASGDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 1023
Danio rerio	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 2067 +\|\|+\| \| \|\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2051 VASKDVGQTVDEVEKLLKRHEAFEKSTATW#EERFSALERLTTLEL 2095
Gallus gallus	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 2067 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|\|\|\|\|+ \|\|\|\|\| Sbjct 2039 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFAALERLTTLEL 2083
Canis familiaris	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 2067 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2040 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 2084
Pan troglodytes	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 2067 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2040 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 2084
Rattus norvegicus	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 2067 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2035 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 2079
Macaca mulatta	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 2067 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2027 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 2071
Bos taurus	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 2067 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2039 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 2083
Macaca fascicularis	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 2067 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 370 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 414
mice, brain, Peptide Partial, 332 aa	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 2067 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 166 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 210
Tetraodon nigroviridis	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTL 2065 \|+\|\|+ \| +\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|+ Sbjct 1940 LSSREVGRSVDQVEKLLKRHEAFEKSAATW#EERFSALERLTTV 1982
Drosophila melanogaster	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|\| Sbjct 2041 LLSSELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELK 2086
Aedes aegypti	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|\| Sbjct 2041 LMSTELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELK 2086
Drosophila pseudoobscura	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|\| Sbjct 2041 LLSSELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELK 2086
Anopheles gambiae str. PEST	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|\| Sbjct 2041 LMSTELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELK 2086
Tribolium castaneum	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|+ Sbjct 2040 LMSTELGHTIDDVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELR 2085
Apis mellifera	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \|++ \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\| + \|\| \|\|\| Sbjct 2039 LMSQELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALHRLTTFELK 2084
Strongylocentrotus purpuratus	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \| \|+\| ++\| \|\|\|\|\|\|\|\|\|\|\|\|\|+ # \|\|\| \|\|\|\| \|\| \|\|+ Sbjct 2029 LRSDDYGDSLDEVEKLIKRHEAFEKALYCQ#EERFTALEKLTTFELR 2074
Caenorhabditis briggsae	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \|\|++\| ++ \|\|\|\|+\|\|\|\|\|\|\| + # \|\|\| \|\|\|\| \|\| \|\|\| Sbjct 2027 LISREYGRNLEETIKLIKKHEAFEKSALAQ#EERFLALEKLTTFELK 2072
Brugia malayi	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \|+++\| ++ \|\|\|\|+\|\|\|\|\|\|\| + # \|\|\| \|\|\|\| \|\| \|\|\| Sbjct 2036 LVSKEYGRNLEETIKLIKKHEAFEKSANAQ#EERFLALEKLTTFELK 2081
Caenorhabditis elegans	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \| \|+++\| ++ \|\|\|\|+\|\|\|\|\|\|\| + # \|\|\| \|\|\|\| \|\| \|\|\| Sbjct 2030 LISKEYGRNLEETIKLIKKHEAFEKSAFAQ#EERFLALEKLTTFELK 2075
Sus scrofa	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTT 2064 \| + \| \| ++\|\|\|\| \|+\|+\|\| \|\|\|\| ++ # \|+ \|\|++ \| Sbjct 27 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQ#EEKITALDEFVT 68
Monodelphis domestica	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2028 LASRDFGHTVDSVEKLIKRHEAFEKSTAPW#AERFAALEKPTTLELK 2073 Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALE 2060 +\| +\|\|+ + +\|\| \|+\|\|\| \| \|\|++# \|\| \|\|\| Sbjct 444 VAQDNFGYDLAAVEAAKKKHEAIETDTAAY#EERVKALE 481
Mus sp.	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 2068 Query 2027 DFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALE 2060 +\|\|+ + +\|\| \|+\|\|\| \| \|\|++# \|\| \|\|\| Sbjct 441 NFGYDLAAVEAAKKKHEAIETDTAAY#EERVKALE 474
Xenopus tropicalis	Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTT 2064 \| + \| \| ++\|\|\|\| \|+\|+\|\| \|\|\|\| ++ # \|+ \|\|++ \| Sbjct 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQ#EEKITALDEFAT 531 Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALE 2060 \| \| \| \| ++\|\|\|\| \|\|\|+\|\| \|+\|+ # \|+ \|\|\|+ Sbjct 1467 LNSEDKGDSLDSVEALIKKHEDFDKAINVQ#EEKIAALQ 1504 Query 2023 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAAL 2059 +\|\| \|\|\| + \|\|+ \|+++\|\| \|+ \|+ # \|+ \|\| Sbjct 278 MASDDFGRDLASVQALLRKHEGLERDLAAL#EEKVKAL 314 Query 2023 LASRDFGHTVDSVEKLIKRHEAFE 2046 +\|\| \|+\| \|+ +++ \|+\|+\|\|\|\|\| Sbjct 1892 VASEDYGDTLAAIQGLLKKHEAFE 1915

* References

[PubMed ID: 8219239] Bloom ML, Birkenmeier CS, Barker JE, Complete nucleotide sequence of the murine erythroid beta-spectrin cDNA and tissue-specific expression in normal and jaundiced mice. Blood. 1993 Nov 1;82(9):2906-14.

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