CaMPDB :: Substrate

XSB2936 : nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Sus scrofa]

This entry is computationally expanded from SB0011

* Basic Information

Organism	Sus scrofa (pig)
Protein Names	NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; ECI-6; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor; alpha
Gene Names	NFKBIA; IKBA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Gene Locus	7q15-q21; chromosome 7
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_001005150	NM_001005150	406188	IKBA_PIG	N/A	N/A	N/A	ssc:406188

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 314 aa

Average Mass: 35.230 kDa

Monoisotopic Mass: 35.208 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Toxin_36 1.	39	51	7.2	8.6
--- cleavage 50 (inside Toxin_36 39..51) ---
Ank 1.	73	109	6.7	4
Ank 2.	110	142	35.7	1.9e-07
Ank 3.	143	180	17.7	0.049
Ank 4.	182	214	43.0	1.2e-09
Ank 5.	216	248	42.7	1.4e-09
SNN_linker 1.	273	298	4.7	6.4

3. Sequence Information

Fasta Sequence: XSB2936.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] EYEQMVKELR⁵⁰-EIRLEPQEAP

Arg⁵⁰ Glu

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Glu⁴¹	Tyr⁴²	Glu⁴³	Gln⁴⁴	Met⁴⁵	Val⁴⁶	Lys⁴⁷	Glu⁴⁸	Leu⁴⁹	Arg⁵⁰

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Glu⁵¹	Ile⁵²	Arg⁵³	Leu⁵⁴	Glu⁵⁵	Pro⁵⁶	Gln⁵⁷	Glu⁵⁸	Ala⁵⁹	Pro⁶⁰

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
KKERLLDDRHDSGLDSMKDEEYEQMVKELREIRLEPQEAPRGAEPWKQQLTEDGDSFLHL

Summary

#	organism	max score	hits	top seq
1	Bos taurus	126.00	1	nuclear factor of kappa light polypeptide gene enh
2	Sus scrofa	126.00	1	nuclear factor of kappa light polypeptide gene enh
3	Canis familiaris	125.00	1	PREDICTED: similar to nuclear factor of kappa ligh
4	Macaca mulatta	123.00	3	PREDICTED: similar to nuclear factor of kappa ligh
5	synthetic construct	122.00	2	Homo sapiens nuclear factor of kappa light polypep
6	Homo sapiens	122.00	1	nuclear factor of kappa light polypeptide gene enh
7	Mus musculus	119.00	3	IKBA_MOUSE NF-kappa-B inhibitor alpha (I-kappa-B-a
8	Meriones unguiculatus	119.00	1	I-kappa-B-alpha
9	Rattus rattus	117.00	1	IKBA_RAT NF-kappa-B inhibitor alpha (I-kappa-B-alp
10	Rattus norvegicus	117.00	1	PREDICTED: similar to NF-kappaB inhibitor alpha (I
11	Monodelphis domestica	105.00	1	PREDICTED: similar to NF-kappa-B inhibitor alpha (
12	Gallus gallus	86.30	2	IKBA_CHICK NF-kappa-B inhibitor alpha (I-kappa-B-a
13	Xenopus laevis	68.60	2	MGC80640 protein
14	Xenopus tropicalis	66.60	1	nuclear factor of kappa light polypeptide gene enh
15	Oncorhynchus mykiss	66.20	1	inhibitor of nuclear factor kappa B alpha
16	Paralichthys olivaceus	53.50	1	inhibitor kappa B alpha
17	Danio rerio	52.80	4	NF-kappaB inhibitor alpha-like protein A
18	Tetraodon nigroviridis	50.40	2	unnamed protein product
19	Siniperca chuatsi	49.70	2	I kappa B alpha

Top-ranked sequences

organism	matching
Bos taurus	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80
Sus scrofa	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80
Canis familiaris	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 222 KKERLLDDRHDSGLDSMKDEEYEQLVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 281
Macaca mulatta	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGAEPWKQQLTEDGDSFLHL 80
synthetic construct	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\|\| \|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL 80
Homo sapiens	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\|\| \|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL 80
Mus musculus	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 21 KKERLVDDRHDSGLDSMKDEEYEQMVKELR#EIRLQPQEAPLAAEPWKQQLTEDGDSFLHL 80
Meriones unguiculatus	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 21 KKERLVDDRHDSGLDSMKDEEYEQMVKELR#EIRLQPQEAPAAAEPWKQQLTEDGDSFLHL 80
Rattus rattus	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|#\|\|\|\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 21 KKERLVDDRHDSGLDSMKDEDYEQMVKELR#EIRLQPQEAPLAAEPWKQQLTEDGDSFLHL 80
Rattus norvegicus	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|#\|\|\|\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 21 KKERLVDDRHDSGLDSMKDEDYEQMVKELR#EIRLQPQEAPLAAEPWKQQLTEDGDSFLHL 80
Monodelphis domestica	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRG--AEPWKQQLTEDGDSFL 78 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\| \|\|\|\|\|+#\|\|\|++\|\|\|\| \| \|\|\|\|\|\|+\|\|\|\|\|\|\|\| Sbjct 78 KKERLLDDRHDSGLDSMKDEDYELMVKELK#EIRIQPQEAQPGPPQEPWKQQVTEDGDSFL 137 Query 79 HL 80 \|\| Query 79 HL 80
Gallus gallus	Query 27 DDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL 80 \|\|\|\|\|\|\|\|\|\|\|\|+\|\|\| \|+\|+\|\| #+\|\|\|+\|+\| \| \| \|\|\|\|\|\|\|\|+\|\|\|\| Sbjct 31 DDRHDSGLDSMKEEEYRQLVRELE#DIRLQPREPPARPHAWAQQLTEDGDTFLHL 84
Xenopus laevis	Query 21 KKERLL-DDRHDSGLDSMKDEEYEQMVKELR#EIRLE-PQEAPR-GAEPWKQQLTEDGDSF 77 +\|++\|\| \|\|\| \|\|\|\|\|\|+\|++\|\| ++\|++ #\|+\|++ \| + \| \|\|\|\|+++ \|\|\|\|+\| Sbjct 21 RKDKLLQDDRFDSGLDSLKEDEYTAIMKDIN#ELRIDVPSDTPYCEPEPWKKEVNEDGDTF 80 Query 78 LHL 80 \|\|\| Query 78 LHL 80
Xenopus tropicalis	Query 21 KKERLL-DDRHDSGLDSMKDEEYEQMVKELR#EIRLE--PQEAPRGAEPWKQQLTEDGDSF 77 +\|++\|\| \|\|\| \|\|\|\|\|\|+\|+\|\|\| ++ +\| # +\|+\| \| + \|\|\|\|+++ \|\|\|\|+\| Sbjct 21 RKDKLLQDDRIDSGLDSLKEEEYTAIITDLS#NMRMEGPPDTSNYEPEPWKKEVNEDGDTF 80 Query 78 LHL 80 \|\|\| Query 78 LHL 80
Oncorhynchus mykiss	Query 27 DDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGA---EPWKQQLTEDGDSFLHL 80 +\|\| \|\|\|\|\|\|+\|\|+\|\| +\|\|\|\| #++\|+ \| \| + \|\|\|++ +\|\|\| \|+\|\|\|\| Sbjct 31 EDRFDSGLDSLKDDEYGNLVKELE#DLRVAPVEVKSNSCSNEPWRKTVTEDRDTFLHL 87
Paralichthys olivaceus	Query 27 DDRHDSGLDSMKDEEYEQMVKELR#EIRL-----EPQEAPRGAE---PWKQQLTEDGDSFL 78 ++\| \|\|\|\|\|\|+\|+\|\|\|+ + \|+\|# +++ + +++\| \| \|\| \|+\|\|\|\|\|+ \| Sbjct 29 EERLDSGLDSLKEEEYQAVAAEIR#GLQVSCDPPQHRQSPAACEEQSEWKTQVTEDGDTLL 88 Query 79 HL 80 \|\| Query 79 HL 80
Danio rerio	Query 21 KKERLLDDRHDSGLDSMKDEEYE--QMVKELR#EIRLEPQEAPRG-AEPWKQQLTEDGDSF 77 +\| + +\|\| \|\|\|+\|\|+\|+\|\|\|\| ++ +\|+ # + ++ \|\|\| + +\|\|\|\|\|++ Sbjct 24 RKTQQCEDRVDSGVDSLKEEEYETREISEEME#RLTIQTASLKETICEPWAKVVTEDGDTY 83 Query 78 LHL 80 \|\|\| Query 78 LHL 80
Tetraodon nigroviridis	Query 21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEP--------WKQQLTE 72 \| + \|+\| \|\|\|\|\|\|+++\|\|\| # +\|+\| + \| \|\| \|\| \|+\|\| Sbjct 11 KPAQATDERLDSGLDSLREEEY--------#RLRVECEPPPHKPEPAAAAELPEWKTQVTE 62 Query 73 DGDSFLHL 80 \|\|\|+ \|\|\| Sbjct 63 DGDTLLHL 70
Siniperca chuatsi	Query 27 DDRHDSGLDSMKDEEYEQMVKELR#EIRLE-PQEAPRGAEPWKQQLTEDGDSFLHL 80 +\|\| \|\|\|\|\|\|+\|++\| +\| + #++ + ++ \| \|\|\|+ +\|\|\|\|\|+ \|\|\| Sbjct 31 EDRFDSGLDSLKEDE---LVNDFE#DMTVNISEDVPPEYEPWRSAVTEDGDTLLHL 82

* References

[PubMed ID: 14681463] Uenishi H, Eguchi T, Suzuki K, Sawazaki T, Toki D, Shinkai H, Okumura N, Hamasima N, Awata T, PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D484-8.

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